Relationship between COVID-19 and intrauterine growth restriction
Keywords:
fetal growth retardation, pregnancy, COVID-19Abstract
Introduction: Intrauterine growth restriction is one of the main complications of pregnancy and can be caused by viral infections. Objective: To evaluate the relationship between COVID-19 and intrauterine growth restriction. Methods: A narrative bibliographic review was conducted of articles published between 2020 and 2024 in scientific databases such as: Web of Sciences, SCOPUS, SciELO, PubMed/Medline, and Google Scholar. 28 articles that met the previously defined criteria were selected. Conclusions: Maternal complications caused by COVID-19 are mainly due to placental damage, either through direct viral invasion or through immune mechanisms activated by the infection that damage the placenta. This reinforces the importance of maintaining and complying with health measures for the prevention of COVID-19 in pregnant women, to avoid complications.
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1.Yang L, Feng L, Huang L, Li X, Qiu W, Yang K, et al. Maternal Factors for Intrauterine Growth Retardation: Systematic Review and Meta-Analysis of Observational Studies. Reprod Sci. 2023; 30(6):1737-45. doi: https://doi.org/10.1007/s43032-021-00756-3.
2. Rybertt T, Azua E, Rybertt F. Retardo de crecimiento intrauterino: consecuencias a largo plazo. Rev Med Clin Condes. 2016; 27(4):509-13. doi: https://doi.org/10.1016/j.rmclc.2016.07.010
3.Levine TA, Grunau RE, McAuliffe F; Pinnamaneni R; Foran A; Alderdice F, et.al. Early Childhood Neurodevelopment After Intrauterine Growth Restriction: A Systematic Review. Pediatrics. 2015; 135(1):126-41. doi: https://doi.org/10.1542/peds.2014-1143
4. Tamayo Pérez VI, Morilla Guzmán AA, Lauzurique ME. Restricción del crecimiento intrauterino y enfermedades no transmisibles durante las edades pediátricas. Rev Cubana Pediatría [Internet]. 2023 [citado 20 Ene 2025]; 95:e3982. Disponible en: https://revpediatria.sld.cu/index.php/ped/article/view/3982
5. Moreno KF, Ayala FD, Guevara E, Carranza C, Mambret AM. Prevalencia y factores obstétricos asociados a restricción del crecimiento fetal intrauterino. Rev Peruana Investig Matern Perinat [Internet]. 2021[citado 20 Ene 2025];10(4): 36-43. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=8510524
6. San José Pérez DM, Mulet Bruzón BI, Rodríguez Noda O, Legrá García M. Factores maternos relacionados con el bajo peso al nacer. Rev Cubana Obst Gin [Internet]. 2011[citado 20 Ene 2025]; 37(4):489-501. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-600X2011000400006&lng=es
7. Chibas-Muñoz E, Herrera-Ortega S, Creagh-Bandera R, Columbié-Méndez B, Sánchez-García A. Comportamiento clínico-epidemiológico del crecimiento intrauterino retardado en gestantes del Hospital General Docente “Dr. Agostinho Neto”. Gaceta Médica Estudiantil [Internet]. 2021[citado 20 Ene 2025]; 2(1):1-10. Disponible en: https://revgacetaestudiantil.sld.cu/index.php/gme/article/view/5/8
8. Bekkhus M, Oftedal A, Braithwaite E, Haugen G, Kaasen A. Paternal Psychological Stress After Detection of Fetal Anomaly During Pregnancy. A Prospective Longitudinal Observational Study. Front Psychol. 2020; 11:1848. doi: https://doi.org/10.3389/fpsyg.2020.01848
9. Beune IM, Damhuis SE, Ganzevoort W, Hutchinson JC, Khong, TY, Mooney EE, et al. Consensus Definition of Fetal Growth Restriction in Intrauterine Fetal Death. A Delphi Procedure. Arch Pathol Lab Med. 2021; 145:428-36. doi: https://doi.org/10.5858/arpa.2020-0027-OA.
10. Godoy GM, Zacur M. Restricción de crecimiento intrauterino. Causas, características clínicas, y evaluación de factores asociados a policitemia sintomática. Rev Chilena Ped. 2010; 81(4): 366 - 8. doi: http://dx.doi.org/10.4067/S0370-41062010000400013
11. Chen M, Zeng J, Liu X, Sun G, Gao Y, Liao J, et al. Changes in physiology and immune system during pregnancy and coronavirus infection: A review. Eur J Obstet Gynecol Reprod Biol. 2020; 255:124-8. doi: https://doi.org/10.1016/j.ejogrb.2020.10.035
12. Gámez-Gámez LN, Gámez-Borges LN, José-Sorrillo L, Matos-Quiala HA. Influencia de la COVID-19 en el embarazo desde la perspectiva de los cuidados intensivos. Rev Inf Cient [Internet]. 2021[citado 20 Ene 2025];100(4):e3351. Disponible en: https://revinfcientifica.sld.cu/index.php/ric/article/view/3351/4844
13. Auriti C, De Rose DU, Tzialla C, Caforio L, Ciccia M, Manzoni P, et al. Vertical Transmission of SARS-CoV-2 (COVID-19): Are Hypotheses More Than Evidences? Am J Perinatol. 2020; 37(S02):S31–8. doi: https://doi.org/10.1055/s-0040-1714346
14.Faure-Bardon V, Isnard P, Roux N, Leruez-Ville M, Molina T, Bessieres B, et al. Protein Expression of Angiotensin-Converting Enzyme 2, a SARSCoV-2-Specific Receptor, in Fetal and Placental Tissues Throughout Gestation: New Insight for Perinatal Counseling. Ultrasound Obstetrics Gynecol[Internet]. 2021[citado 21 Jun 2025];57(2):242–7. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7461228
15.Rad HS, Röhl J, Stylianou N, Allenby MC, Bazaz SR, Warkiani ME, et al. The Effects of COVID-19 on the Placenta During Pregnancy. Front Immunol. 2021;12:743022. doi: https://doi.org/10.3389/fimmu.2021.743022
16.Chen S, Huang B, Luo DJ, Li X, Yang F, Zhao Y, et al. Pregnancy with new coronavirus infection: Clinical characteristics and placental pathological analysis of three cases. Chin J Pathol. 2020;49(5):418-23.doi: https://doi.org/10.3760/cma.j.cn112151-20200225-00138
17.Patberg ET, Adams T, Rekawek P, Vahanian SA, Akerman M, Hernandez A, et al. Coronavirus disease 2019 infection and placental histopathology in women delivering at term. Am J Obstet Gynecol. 2021; 224(4):382.e1-382.e18. doi: https://doi.org/10.1016/j.ajog.2020.10.020.
18. Hcini N, Maamri F, Picone O, Carod JF, Lambert V, Mathieu, et al. Maternal, fetal and neonatal outcomes of large series of SARS-CoV-2 positive pregnancies in peripartum period: a single-center prospective comparative study. Eur J Obstet Gynecol Reprod Biol. 2021; 257:11-8. doi: https://doi.org/10.1016/j.ejogrb.2020.11.068
19. Maloof G, Rodríguez MJ, Moreno F. COVID-19 y embarazo: repercusiones maternas y neonatales. Una revisión de la literatura. Univ Med. 2021; 62(4): [Aprox. 8p.]. doi: https://doi.org/10.11144/javeriana.umed62-4.emba
20. Badr DA, Picone O, Bevilacqua E, Carlin A, Meli F, Sibiude J, et al. Severe acute respiratory syndrome coronavirus 2 and pregnancy outcomes according to gestational age at time of infection. Emerg Infect Dis[Internet].2021[citado 21 Jul 2025];27(10):2535–43. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC8462348
21.Papapanou M, Papaioannou M, Petta A, Routsi E, Farmaki M, Vlahos N, et al. Maternal and neonatal characteristics and outcomes of COVID-19 in pregnancy: an overview of systematic reviews. Int J Environ Res Public Health.2021;18(2):596. doi: https://doi.org/10.3390/ijerph18020596.
22. Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur J Med Res.2020;25(39):1-14. doi: https://doi.org/10.1186/s40001-020-00439-w
23. Bahrami R, Schwartz DA, Karimi-Zarchi M, Javaheri A, Dastgheib SA, Ferdosian F, et al. Meta-analysis of the frequency of intrauterine growth restriction and preterm premature rupture of the membranes in pregnant women with COVID-19. Turk J Obstet Gynecol. 2021;18(3):236-44. doi: https://doi.org/10.4274/tjod.galenos.2021.74829.
24. Narang K, Miller M, Trinidad C, Wick M, Theiler R, Weaver AL, et al. Impact of asymptomatic and mild COVID-19 infection on fetal growth during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2023;281:63-7. doi: https://doi.org/10.1016/j.ejogrb.2022.12.020.
25.Elbehery M, Munshi FA, Alzahrani A, Bakhsh M, Alariefy M. COVID-19 in an Intrauterine Growth Restriction (IUGR) Infant with Congenital Heart Disease: Case Report and Literature Review. Cureus. 2020;12(9):e10294. doi: https://doi.org/10.7759/cureus.10294
26. Zafman KB, Cudjoe E, Levine LD, Srinivas SK, Schwartz N. Undetected Fetal Growth Restriction During the Coronavirus Disease 2019 (COVID-19) Pandemic. Obstet Gynecol. 2023;141(2):414-7. doi: https://doi.org/10.1097/AOG.0000000000005052
27.Messina A, Mariani A, Dalmasso E, Leo L, Manzoni P, Masturzo B. Coronavirus Infection During Pregnancy and Fetal Growth: How Should We Monitor These Pregnancies? A Literature Review. Ann Clin Med Case Rep[Internet]. 2024[citado 4 Ene 2025];14(6): 1-6. Disponible en: https://acmcasereport.org/wp-content/uploads/2024/11/ACMCR-v14-2292.pdf
28.Metz TD, Clifton RG, Hughes BL, Sandoval G, Saade GR, Grobman WA, et al. Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19). Obstet Gynecol. 2021;137(4):571-80. doi: https://doi.org/10.1097/AOG.0000000000004339
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Copyright (c) 1970 Melvis Garcés Rodríguez, Odalis Pérez Castro , Anavir Leyva Labrada
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