Delayed Paternity: influence in children´s health

Authors

Keywords:

paternity, pregnancy, health, children

Abstract

Modern reproductive behavior in Cuba and other countries of the world, is characterized by a delay in paternity, due to the increasing of life expectancy, to socioeconomic situations, a higher access to assisted reproduction techniques; among others. Physiological changes related to age, affect the male reproductive system. It has been shown that advanced paternal age is associated to disorders in reproductive hormone levels, decreasing of the testicular and sexual function as well as the production of sperm. Epidemiological studies have evidenced that the advanced paternal age, in the moment of the conception, is associated to a higher risk of novo mutations, which have significant effects in pregnancy and in children. To stimulate an adequate control of the preconception risk , including the stimulation of the conception of pregnancy in optimal ages, constitute a challenge in modern society and a necessity of the children in the future.

Downloads

Download data is not yet available.

Author Biography

Daniel Quintana Hernández, Hospital Materno Infantil "Manuel Piti Fajardo", Mayabeque.

Doctor en Ciencias Médicas. Especialista de I grado en Medicina General Integral. Especialista de I y II grado en Genética Clínica. Profesor Auxiliar de Genética Médica. Máster en Atención Integral al Niño. Investigador Auxiliar. Centro Provincial de Genética Médica Mayabeque.

References

Goisis A, Håberg SE, Hanevik HI, Magnus MC, Kravdal Ø. The demographics of assisted reproductive technology births in a Nordic country. Hum Reprod. 2020 Jun 1;35(6):1441-50. doi: https://doi.org/10.1093/humrep/deaa055

Ashapkin V, Suvorov A, Pilsner JR, Krawetz SA, Sergeyev O. Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development. Hum Reprod Update. 2023 Jan 5;29(1):24-44. doi: https://doi.org/10.1093/humupd/dmac033

Paoli D, Pecora G, Pallotti F, Faja F, Pelloni M, Lenzi A, et al. Cytological and molecular aspects of the ageing sperm. Hum Reprod. 2019 Feb 1;34(2):218-27. doi: https://doi.org/10.1093/humrep/dey357

Evenson DP, Djira G, Kasperson K, Christianson J. Relationships between the age of 25,445 men attending infertility clinics and sperm chromatin structure assay (SCSA®) defined sperm DNA and chromatin integrity. Fertil Steril. 2020 Aug;114(2):311-20. doi: https://doi.org/10.1016/j.fertnstert.2020.03.028

Marcho C, Oluwayiose OA, Pilsner JR. The preconception environment and sperm epigenetics. Andrology. 2020 Jul;8(4):924-42. doi: https://doi.org/10.1111/andr.12753

Smits RM, Xavier MJ, Oud MS, Astuti GDN, Meijerink AM, de Vries PF, et al. De novo mutations in children born after medical assisted reproduction. Hum Reprod. 2022 May 30;37(6):1360-9. doi: https://doi.org/10.1093/humrep/deac068

Goldmann JM, Veltman JA, Gilissen C. De Novo mutations reflect development and aging of the human germline. Trends Genet[Internet].2019 Nov[citado 26 Abr 2023];35(11):828-39. Disponible en: https://www.sciencedirect.com/science/article/pii/S0168952519301787?via%3Dihub https://doi.org/10.1016/j.tig.2019.08.005

Yatsenko AN, Turek PJ. Reproductive genetics and the aging male. J Assist Reprod Genet[Internet]. 2018 Jun[citado 26 Abr 2023];35(6):933-41. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030011/ https://doi.org/10.1007/s10815-018-1148-y

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5.ed. Washington DC: American Psychiatric Association; 2013. Disponible en: https://www.appi.org/Diagnostic_and_Statistical_Manual_of_Mental_Disorders_DSM5_Fifth_Edition

Halvaei I, Litzky J, Esfandiari N. Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health. Reprod Biol Endocrinol[Internet]. 2020[citado 26 Abr 2023];18(1):110. Disponible en: https://rbej.biomedcentral.com/articles/10.1186/s12958-020-00668-y https://doi.org/10.1186/s1295802000668y

Sandin S, Schendel D, Magnusson P, Hultman C, Surén P, Susser E, et al. Autism risk associated with parental age and with increasing difference in age between the parents. Mol Psychiatry. 2016 May;21(5):693-700. doi: https://doi.org/10.1038/mp.2015.70

Quintana Hernández D, Lantigua Cruz PA, Tamargo Barbeito TO, Calixto Robert Y, Hernández Hernández N. Factores de riesgos heredofamiliares, prenatales y perinatales en niños cubanos con autismo primario. Rev Haban Cienc Méd [Internet]. 2022[citado 26 Abr 2023]; 21(4):1-10. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/4687

Código de las Familias [Internet]. Gaceta Oficial de la República de Cuba. Ley 156/2022 (GOC-2022-819-O87). La Habana: Gaceta Oficial de la República de Cuba; 2022. [citado 26 Abr 2023]. Disponible en: https://www.parlamentocubano.gob.cu/sites/default/files/documento/2022-08/goc-2022-o87.pdf

Downloads

Published

2023-06-29

How to Cite

1.
Quintana Hernández D. Delayed Paternity: influence in children´s health. Medimay [Internet]. 2023 Jun. 29 [cited 2024 Oct. 16];30(2):132-4. Available from: https://medimay.sld.cu/index.php/rcmh/article/view/2453

Issue

Vol. 30 No. 2 (2023)

Section

EDITORIAL

License

Medimay protects copyright from the very first moment the submission is made, but upon publication it assumes a Creative Commons 4.0 (cc-by-nc) license, which allows the use of the work to share (copy and redistribute the material in any medium or format) and adapt (remix, transform and build from the material) as long as exclusive mention is made of the publication in the journal as a primary source, prohibiting its commercialization. The author always retains his/her right.

Most read articles by the same author(s)