Affectation of the nervous system because of dengue

Authors

Keywords:

dengue, neurotropism, neurological manifestations, psychiatric

Abstract

Dengue is the most frequent viral infection transmitted by mosquitoes; in the last years its incidence has increased. The virus is transmitted by Aedes aegypti and, in lower degrees, by the specie Aedes albopictus. Impact of dengue may have devastated consequences. It is important for health professionals, to know the characteristics of the disease and its affectation of the nervous system, whenever the virus has a defined neurotropism. The objective of this article is to revise the affectation of the nervous system for this disease. Google scholar and the descriptors dengue, neurological and psychiatric manifestations were used. The data bases Medline, Scielo, Scopus y Medscape were also used. Dengue can present affectation of the nervous system in form of nonspecific acute neurological symptoms, acute encephalitis or focal neurological symptoms and post-infectious neurological complications.

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Author Biographies

Juan Enrique Bender del Busto, Centro Internacional de Restauración Neurológica (CIREN) .La Habana.

Doctor en Ciencias Médicas, Especialista de II grado en Neurología Investigador Titular. Profesor Titular y Consultante. Centro Internacional de Restauración Neurológica. Instituto de Ciencias Básicas y Preclínicas ̈Victoria de Girón ̈. La Habana

Marcel Deniel Mendieta Pedroso, Dirección Provincial de Salud. . San José de las Lajas. Mayabeque

Doctor en Ciencias Médicas. Especialista de I y II grado en Medicina Interna. Especialista de I y II grado en Medicina General Integral. Máster en Urgencias Médicas. Investigador Agregado. Profesor Auxiliar. Dirección Provincial de Salud. Facultad de Ciencias Médicas de Mayabeque.

Héctor Vera Cuesta, Centro Internacional de Restauración Neurológica. La Habana

Especialista de II Grado en Neurología, Máster en Genética.Investigador Agregado.Profesor Auxiliar. Centro Internacional de Restauración Neurológica.Instituto de Ciencias Básicas y Preclínicas ̈Victoria de Girón ̈. La Habana.

References

Carod-Artal FJ. Complicaciones neurológicas asociadas a la infección por el virus del dengue. Rev Neurol[Internet]. 2019[citado 28 Oct 2022];69(03):113-22. Disponible en: https://neurologia.com/articulo/2019140

Organización Panamericana de la Salud / Organización Mundial de la Salud. Actualización Epidemiológica: Dengue[Internet]. 11 Nov 2019. Washington, DC: OPS/OMS; 2019. Disponible en: https://www3.paho.org/hq/index.php?option=com_docman&view=download&category_slug=dengue-2158&alias=50965-11-de-noviembre-de-2019-dengue-actualizacion-epidemiologica-1&Itemid=270&lang=es

Dinakaran D, Sreeraj VS, Venkatasubramanian G. Dengue and Psychiatry: Manifestations, Mechanisms, and Management Options. Indian J Psychol Med[Internet]. 2022 Sep[citado 28 Oct 2022];44(5):429–35. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460008/ .

Tamayo Escobar OE, García Olivera TM, Escobar Yéndez NV, González Rubio D, Castro Peraza O. La reemergencia del dengue: un gran desafío para el sistema sanitario latinoamericano y caribeño en pleno siglo XXI.

Medisan[Internet]. 2019[citado 28 Oct 2022];23(2):308-24. Disponible en: https://www.medigraphic.com/pdfs/medisan/mds-2019/mds192j.pdf

Organización Mundial de la Salud. Dengue and severe dengue [Internet]. 10 Jan 2022 Washington, DC: OMS; 2022. Disponible en: Disponible en: https://www.who.int/en/news-room/fact-sheets/detail/dengue-and-severe-dengue

Bentes A, Geessien E, Castro R. Neurological manifestations of pediatric arboviral infections in the Americas. Journal of Clinical Virology [Internet]. 2019[citado 28 Oct 2022];116:

–57. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1386653219300940?via%3Dihub

Sabir M J, Al-Saud N B S, Hassan S M. Dengue and human health: A global scenario of its occurrence, diagnosis and therapeutics. Saudi J Biol Sci [Internet]. 2021[citado 28 Oct 2022]; 28(9):5074-80. Disponible en: https://www.sciencedirect.com/science/article/pii/S1319562X21003910?via%3Dihub doi: https://doi.org/10.1016/j.sjbs.2021.05.023

Erazo, R. Complicaciones neurológicas Chikungunya y dengue. Pediátr Panamá [Internet]. 2017[citado 28 Oct 2022];46(2):46-51. Disponible en: https://docs.bvsalud.org/biblioref/2017/08/848278/46-51.pdf

Gan ES, Ting DHR, Chan KR. The mechanistic role of antibodies to dengue virus in protection and disease pathogenesis. Expert Rev Anti Infect Ther[Internet]. 2017[citado 28 Oct 2022];15(2):111-19. Disponible en: https://www.tandfonline.com/doi/full/10.1080/14787210.2017.1254550

Basurko C, Matheus S, Hildéral H, Everhard S, Restrepo M, Cuadro Alvarez E, et al., Estimating the Risk of Vertical Transmission of Dengue: A Prospective Study. American Journal of Tropical Medicine and Hygiene [Internet]. 2018[citado 28 Oct 2022];98(6):1826-32. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086150/pdf/tpmd160794.pdf

Diaz Angarita TF, Moreno Sánchez A, Cárdenas Parra KL. Encefalitis por dengue. Pediatria [Internet]. 2022 [citado 28 Oct 2022];54(4):163-6. Disponible en: https://revistapediatria.org/rp/article/view/238

Centros para el Control y la Prevención de Enfermedades [Internet]. Atlanta: Centros para el Control y la Prevención de Enfermedades; 2019. Dengue: Cuadro clínico. [actalizado 5 Sep 2019, citado 28 Oct 2022]. Disponible en: https://www.cdc.gov/dengue/es/healthcare-providers/clinical-presentation.html

Li GH, Ning ZJ, Liu YM, Li XH. Neurological Manifestations of Dengue Infection. Front Cell Infect Microbiol[Internet]. 2017[citado 28 Oct 2022];7:449. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660970/pdf/fcimb-07-00449.pdf

González-Losada C, Lozano García M. Trastornos neurológicos asociados a la infección por virus dengue. Rev Cubana Med [Internet]. 2020 Dic [citado 28 Oct 2022];59(4):e1162. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232020000400009&lng=es

Yamani N, Olesen J. New daily persistent headache: A systematic review on an enigmatic disorder. J Headache Pain [Internet]. 2019[citado 28 Oct 2022];20(1):80. Disponible en: https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1022-z

Saini L Chakrabarty B, Pastel H, Israni A, Kumar A, Gulati S. Dengue fever triggering hemiconvulsion hemiplegia epilepsy in a child. Neurol India [Internet]. 2017[citado 28 Oct 2022];65(3):636–8.Disponible en: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2017;volume=65;issue=3;spage=636;epage=638;aulast=Saini

VélIz Castro TI, Contreras Chirinos K, Duran Mojica AA, Pinos Cedeño MJ, Chasillacta Amores FB, Villamar González FJ. Complicaciones neurológicas asociadas a infección por virus dengue: una actualización. Dom Cien[Internet]. 2019[citado 28 Oct 2022];5(1, Especial):

-91. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=7343663

Wilder Smith A, Ooi E E, Horstick O, Wills B. Dengue. Lancet [Internet]. 2019[citado 28 Oct 2022];393(10169):350-63. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0140673618325601 doi: http://10.1016/S0140-6736(18)32560-1 .

Lora-Andosilla M, Almanza-Hurtado A, Rodríguez-Yáñez T, Martínez-Ávila MC y Dueñas-Castell C. Encefalitis como complicación neurológica por dengue. Rev chil infectol [Internet]. 2022 Feb [citado 28 Oct 2022];39(1):91-4. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182022000100091&lng=es.

Bhushan B, Sardana V, Maheshwari D, Ojha P, Mohan S, Moon P, et al. Immune-mediated neurological manifestations of dengue virus- a study of clinico-investigational variability, predictors of neuraxial involvement, and outcome with the role of immunomodulation. Neurol India [Internet]. 2018[citado 28 Oct 2022];66(6):1634-43. Disponible en: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2018;volume=66;issue=6;spage=1634;epage=1643;aulast=Bhushan

Kamel MG, Nam NT, Han NHB, El-Shabouny AE, Makram AM, Abd-Elhay FA, et al.

Post-dengue acute disseminated encephalomyelitis: a case report and meta-analysis. PLoS Negl Trop Dis[Internet]. 2017 [citado 28 Oct 2022 ];11(6):e0005715.Disponible en: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005715

Khoo CS. Dengue cerebellitis: a case report and literatura review. Am J Case Rep [Internet]. 2018[citado 28 Oct 2022];19:864-7.Disponible en: https://amjcaserep.com/abstract/index/idArt/909884

Do Rosário MS, Giovanetti M, De Jesus PAP, Farias DS, Faria NR, De Lima CPS, et al. Opsoclonus-myoclonus-ataxia syndrome associated with chikungunya and dengue virus co-infection. Int J Infect Dis [Internet]. 2018[citado 28 Oct 202 ];75:11-4. Disponible en: https://www.sciencedirect.com/science/article/pii/S1201971218344801?via%3Dihub

Dalugama C, Shelton J, Ekanayake M, Gawarammana IB. Dengue fever complicated with Guillain-Barré syndrome: a case report and review of the literature. J Med Case Rep[Internet]. 2018[citado 28 Oct 2022];12:137. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952700/pdf/13256_2018_Article_1626.pdf

Higgoda R, Perera D, Thirumavalavan K. Multifocal motor neuropathy presenting as a post-infectious complication of dengue: a case report. BMC Infect Dis[Internet]. 2018[citado

Oct 2022];18(1):415. Disponible en: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3334-z

Landais A, Hartz B, Alhendi R, Lannuzel A. Acute mielitis associated with dengue infection. Med Mal Infect [Internet]. 2019[citado 28 Oct 2022];49(4):270-4. Disponible en: https://www.sciencedirect.com/science/article/pii/S0399077X17308247?via%3Dihub

Malik S, Saran S, Dubey A, Punj A. Longitudinally extensive transverse myelitis following dengue virus infection: a rare entity. Ann Afr Med [Internet]. 2018[citado 28 Oct 2022];17(2): 86-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875125/?report=printable

Lana Peixoto MA, Pedrosa D, Talim N, Amaral JMSS, Horta A, Kleinpaul R. Neuromyelitis optica spectrum disorder associated with dengue virus infection. J Neuroimmunol[Internet]. 2018 [citado 28 Oct 2022];318:53-5. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0165572817304897?via%3Dihub

Lana-Peixoto MA, Pedrosa D, Talim N, Amaral JMSS, Lacerda PE, Kleinpaul R. Myelitis and cauda equina involvement following dengue fever. A case report and review of the literature. Mult Scler Relat Disord [Internet].2018[citado 28 Oct 2022];20:48-50. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S221103481730353X?via%3Dihub

Baruah S, Dubey S, Ghavgave U, Jha AN. Dengue fever presenting with cervicodorsal acute spinal spontaneous subdural hematoma-case report and review of literature. World Neurosurg [Internet]. 2019[citado 28 Oct 2022 ];122:272-7. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1878875018325087?via%3Dihub

Verma R, Holla VV, Kumar V, Jain A, Husain N, Malhotra KP, et al. A study of acute muscle dysfunction with particular reference to dengue myopathy. Ann Indian Acad Neurol [Internet]. 2017[citado 28 Oct 2022];20(1):13-22. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341262/pdf/AIAN-20-13.pdf

Li HM, Huang YK, Su YC, Kao CH. Risk of stroke in patients with dengue fever: a population-based cohort study. CMAJ [Internet]. 2018[citado 28 Oct 2022];190(10):

E285-90. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849447/pdf/190e285.pdf

Sam JE, Gee TS. Fatal intracranial hemorrhage in a patient with severe dengue fever. Asian J Neurosurg [Internet]. 2018[citado 28 Oct 2022];13(1):56-8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820895/pdf/AJNS-13-56.pdf

Gunathilaka N, Chandradasa M, Champika L, Siriwardana S,Wijesooriya L. Delayed anxiety and depressive morbidity among dengue patients in a multi-ethnic urban setting: First report from Sri Lanka. Int J Ment Health Syst [Internet]. 2018[citado 28 Oct 2022];12:20. Disponible en: https://ijmhs.biomedcentral.com/articles/10.1186/s13033-018-0202-6

Herbuela V, de Guzman FS, Sobrepeña GD. Depressive and anxiety symptoms among pediatric in-patients with dengue fever: A case-control study. Int J Environ Res Public Health [Internet]. 2019[citado 28 Oct 2022];17(1):1–14. Disponible en: https://www.mdpi.com/1660-4601/17/1/99

Krishnan L, Subramoniam V, Kazhungil F, Tharayil MM .Post dengue mania: A case series. Indian J Psychiatry [Internet]. 2019[citado 28 Oct 2022];61:100–1. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341935/?report=printable

Abdullah M,Bakar M. A case of psychotic disorder due to dengue fever. ASEAN J Psychiatry [Internet]. 2017[citado 28 Oct 2022];18(1):119–22. Disponible en: https://www.aseanjournalofpsychiatry.org/articles/a-case-of-psychotic-disorder-due-to-dengue-fever.pdf

Mohammed AP, Koraddi A, Prabhu A. Rapidly progressive dementia with seizures: a post-dengue complication. Trop Doct[Internet]. 2019[citado 28 Oct 2022]; 50(1): 81–3.Disponible en: https://journals.sagepub.com/doi/10.1177/0049475519885798?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

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Published

2022-12-29

How to Cite

1.
Bender del Busto JE, Mendieta Pedroso MD, Vera Cuesta H. Affectation of the nervous system because of dengue. Medimay [Internet]. 2022 Dec. 29 [cited 2024 Oct. 16];29(4):665-77. Available from: https://medimay.sld.cu/index.php/rcmh/article/view/2319

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Vol. 29 No. 4 (2022)

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