COVID-19 therapeutics based on the structure of SARS-CoV-2

Authors

Keywords:

coronavirus, COVID-19, SARS-CoV-2, S protein S, vaccines, therapeutics

Abstract

Introduction: Knowledge of the structure and the molecular biology of SARS-CoV-2, is important for the design and application of medications against COVID-19.

 Objective:  To describe the therapeutics of COVID-19, based on the structure of SARS-CoV-2

 Methods:  An integrated, non-systematic revision, with the descriptors from DeCS Google Scholar, The Lancet, PubMed Central and SciELO, was performed using articles in Spanish and English, published in 2020 and 2021. 

Conclusions: Among the medications for COVID-19, based on the structure of SARS-CoV-2, there are monoclonal antibodies, inhibitors of the fusion of protease, the viral replication and vaccines. The main used antibodies are: bamlanivimab, etesevimab, casirivimab, imdevimab and meplazumab; among the inhibitors: remdesivir, favipiravir, lopinavir, umifenovir, camastat and péptids (EK1, EK1C4 y HD5). The vaccine platforms use protein sub-units, which are particles similar to a virus, viral vectors, nucleic acids and inactive or attenuated virus

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Author Biographies

Sonia Noemí González Benítez, Escuela Superior Politécnica de Chimborazo. Riobamba.

Especialista en Microbiología. Máster en Enfermedades Infecciosas. Escuela Superior Politécnica de Chimborazo. Riobamba.

Gisela Eduarda Feria Díaz, Escuela Superior Politécnica de Chimborazo. Riobamba.

Especialista de I grado en Medicina General Integral. Escuela Superior Politécnica de Chimborazo. Riobamba,

Alexander Expósito Lara, Escuela Superior Politécnica de Chimborazo. Riobamba.

Especialista en Medicina Crítica y Emergencias. Máster en Urgencias Médicas.Escuela Superior Politécnica de Chimborazo

Pedro Enrique Miguel-Soca, Universidad de Ciencias Médicas de Holguín.

Profesor Auxiliar de Bioquímica Clínica. Máster en Medicina Bioenergética y Natural. Holguín.

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Published

2022-06-21

How to Cite

1.
González Benítez SN, Feria Díaz GE, Expósito Lara A, Miguel-Soca PE. COVID-19 therapeutics based on the structure of SARS-CoV-2. Medimay [Internet]. 2022 Jun. 21 [cited 2024 Nov. 21];29(2):265-86. Available from: https://medimay.sld.cu/index.php/rcmh/article/view/2047

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