Terapéutica de la COVID-19 basada en la estructura del SARS-CoV-2
Palabras clave:
coronavirus, COVID-19, SARS-CoV-2, proteína S, vacunas, terapéutica.Resumen
Introducción:
El conocimiento de la estructura y la biología molecular del SARS-CoV-2, es importante para el diseño y la aplicación de fármacos contra la COVID-19.
Objetivo:
Describir la terapéutica de la COVID-19, basada en la estructura del SARS-CoV-2.
Métodos:
Se realizó una revisión integradora, no sistemática con los descriptores de DeCS en Google Académico, The Lancet, PubMed Central y SciELO, de artículos en español e inglés, publicados en 2020 y 2021.
Conclusiones:
Entre los fármacos contra la COVID-19, basados en la estructura del SARS-CoV-2, se encuentran anticuerpos monoclonales, inhibidores de la fusión de proteasa y de la replicación viral y, las vacunas. Los principales anticuerpos empleados son: bamlanivimab, etesevimab, casirivimab, imdevimab y meplazumab; entre los inhibidores: remdesivir, favipiravir, lopinavir, umifenovir, camastat y péptidos (EK1, EK1C4 y HD5). Las plataformas vacunales emplean subunidades proteicas, partículas semejantes a virus, vectores virales, ácidos nucleicos y virus inactivados o atenuados.
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